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Title:

Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Yoo, Hyunjin; Lee, Young Jae; Park, Chanhyeok; Son, Dabin; Choi, Dong Yoon; Park, Ji-Hyun; Choi, Hee-Jin; La, Hyun Woo; Choi, Yun-Jung; Moon, Eun-Hye; Saur, Dieter; Chung, Hyung Min; Song, Hyuk; Do, Jeong Tae; Jang, Hoon; Lee, Dong Ryul; Park, Chankyu; Lee, Ok-Hee; Cho, Ssang-Goo; Hong, Seok-Ho; Kong, Gu; Kim, Jin-Hoi; Choi, Youngsok; Hong, Kwonho
Abstract:
Proper functioning of the lymphatic system is required for normal immune responses, fluid balance, and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure the correct formation and function of lymphatic vessels; however, the epigenetic modulators and mechanisms involved in this process are poorly understood. Here, we assess the regulatory role of mouse Dot1l, a histone H3 lysine (K) 79 (H3K79) methyltransferase, in lymphatic formation. Genetic ablation of Dot1l in Tie2(+)...     »
Journal title abbreviation:
Cell Death Dis
Year:
2020
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41419-019-2201-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31908356
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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