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Title:

Blocking the road to de-differentiation: HNF1A/KDM6A complex safeguards epithelial integrity in pancreatic cancer.

Document type:
News; Comment
Author(s):
Bärthel, Stefanie; Schneider, Günter; Saur, Dieter
Abstract:
Epithelial differentiation of normal and tumor cells is orchestrated by lineage-determining transcriptional regulatory networks that enforce cell identity. Recent research by Kalisz et al (2020) in the EMBO Journal elucidates the molecular mechanisms by which a transcriptional differentiation program governed by HNF1A and KDM6A maintains acinar differentiation and the epithelial identity of pancreatic ductal adenocarcinoma (PDAC). Loss of function of either transcriptional regulator induces tumo...     »
Journal title abbreviation:
EMBO J
Year:
2020
Journal volume:
39
Journal issue:
9
Fulltext / DOI:
doi:10.15252/embj.2020104759
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32236961
Print-ISSN:
0261-4189
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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