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Title:

Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation.

Document type:
Journal Article
Author(s):
Pfitzinger, Paulo L; Fangmann, Laura; Wang, Kun; Demir, Elke; Gürlevik, Engin; Fleischmann-Mundt, Bettina; Brooks, Jennifer; D'Haese, Jan G; Teller, Steffen; Hecker, Andreas; Jesinghaus, Moritz; Jäger, Carsten; Ren, Lei; Istvanffy, Rouzanna; Kühnel, Florian; Friess, Helmut; Ceyhan, Güralp Onur; Demir, Ihsan Ekin
Abstract:
BACKGROUND: Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progression through inhibition of acetylcholinesterase (AChE) via clinically available AChE-inhibitors, i.e. physostigmine and pyridostigmine. METHODS: We applied immunohistochemistry, immunoblotting, MTT-viability, invasion, flow-cytometric-cell-cycle-assays, phospho-...     »
Journal title abbreviation:
J Exp Clin Cancer Res
Year:
2020
Journal volume:
39
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s13046-020-01796-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33357230
Print-ISSN:
0392-9078
TUM Institution:
591; Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Chirurgie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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