Benutzer: Gast  Login
Titel:

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Martinez-Corral, Ines; Zhang, Yan; Petkova, Milena; Ortsäter, Henrik; Sjöberg, Sofie; Castillo, Sandra D; Brouillard, Pascal; Libbrecht, Louis; Saur, Dieter; Graupera, Mariona; Alitalo, Kari; Boon, Laurence; Vikkula, Miikka; Mäkinen, Taija
Abstract:
Lymphatic malformations (LMs) are debilitating vascular anomalies presenting with large cysts (macrocystic) or lesions that infiltrate tissues (microcystic). Cellular mechanisms underlying LM pathology are poorly understood. Here we show that the somatic PIK3CAH1047R mutation, resulting in constitutive activation of the p110α PI3K, underlies both macrocystic and microcystic LMs in human. Using a mouse model of PIK3CAH1047R-driven LM, we demonstrate that both types of malformations arise due to l...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2020
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-020-16496-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32513927
Print-ISSN:
2041-1723
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
 BibTeX