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Titel:

In Vitro and In Vivo Interspecies Chimera Assay Using Early Pig Embryos.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Nowak-Imialek, Monika; Wunderlich, Stephanie; Herrmann, Doris; Breitschuh-Leibling, Svenja; Gohring, Gudrun; Petersen, Björn; Klein, Sabine; Baulain, Ulrich; Lucas-Hahn, Andrea; Martin, Ulrich; Niemann, Heiner
Abstract:
Chimeric pigs harboring organs derived from human stem cells are promising for patient-specific regenerative therapies. Induced pluripotent stem cells (iPSCs) can contribute to all cell types of the fetus, including germline after injection into embryos. However, ethical concerns prohibit testing human iPSCs in chimera assays. Here, we evaluated porcine embryos as hosts for an interspecies chimera assay using iPSCs from either cynomolgus monkeys (cyiPSCs) or mouse (miPSCs). To establish an in vi...     »
Zeitschriftentitel:
Cell Reprogram
Jahr:
2020
Band / Volume:
22
Heft / Issue:
3
Seitenangaben Beitrag:
118-133
Volltext / DOI:
doi:10.1089/cell.2019.0107
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32429746
Print-ISSN:
2152-4998
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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