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Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hein, Rabea; Sake, Hendrik J; Pokoyski, Claudia; Hundrieser, Joachim; Brinkmann, Antje; Baars, Wiebke; Nowak-Imialek, Monika; Lucas-Hahn, Andrea; Figueiredo, Constanca; Schuberth, Hans-Joachim; Niemann, Heiner; Petersen, Björn; Schwinzer, Reinhard
Titel:
Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class Ilow phenotype-Effects on immune status and susceptibility to human immune responses.
Abstract:
Porcine xenografts lacking swine leukocyte antigen (SLA) class I are thought to be protected from human T cell responses. We have previously shown that SLA class I deficiency can be achieved in pigs by CRISPR/Cas9-mediated deletion of β2 -microglobulin (B2M). Here, we characterized another line of genetically modified pigs in which targeting of the B2M locus did not result in complete absence of B2M and SLA class I but rather in significantly reduced expression levels of both molecules. Residual...     »
Zeitschriftentitel:
Am J Transplant
Jahr:
2020
Band / Volume:
20
Heft / Issue:
4
Seitenangaben Beitrag:
988-998
Volltext / DOI:
doi:10.1111/ajt.15710
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31733031
Print-ISSN:
1600-6135
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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