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Title:

Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA.

Document type:
Journal Article
Author(s):
Niu, Guanglin; Hellmuth, Isabel; Flisikowska, Tatiana; Pausch, Hubert; Rieblinger, Beate; Carrapeiro, Alexander; Schade, Benjamin; Böhm, Brigitte; Kappe, Eva; Fischer, Konrad; Klinger, Bernhard; Steiger, Katja; Burgkart, Reiner; Bourdon, Jean-Christophe; Saur, Dieter; Kind, Alexander; Schnieke, Angelika; Flisikowski, Krzysztof
Abstract:
Recent years have seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a modified TP53 allele that carries a Cre-removable transcriptional stop signal in intron 1, and an oncogenic mutation TP53R167H (orthologous to human TP53R175H) in exon 5. Pigs with the unrecombined mutant allele (flTP53R167H) develop mainly osteosarcoma but also nephroblastomas and lymphomas. This observation suggested that TP53 gene dysfunction...     »
Journal title abbreviation:
Oncogene
Year:
2021
Journal volume:
40
Journal issue:
10
Pages contribution:
1896-1908
Fulltext / DOI:
doi:10.1038/s41388-021-01686-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33603167
Print-ISSN:
0950-9232
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Orthopädie und Sportorthopädie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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