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Title:

Cannabidiol converts NF-κB into a tumor suppressor in glioblastoma with defined antioxidative properties.

Document type:
Journal Article
Author(s):
Volmar, Marie N M; Cheng, Jiying; Alenezi, Haitham; Richter, Sven; Haug, Alisha; Hassan, Zonera; Goldberg, Maria; Li, Yuping; Hou, Mengzhuo; Herold-Mende, Christel; Maire, Cecile L; Lamszus, Katrin; Flüh, Charlotte; Held-Feindt, Janka; Gargiulo, Gaetano; Topping, Geoffrey J; Schilling, Franz; Saur, Dieter; Schneider, Günter; Synowitz, Michael; Schick, Joel A; Kälin, Roland E; Glass, Rainer
Abstract:
BACKGROUND: The transcription factor NF-κB drives neoplastic progression of many cancers including primary brain tumors (glioblastoma [GBM]). Precise therapeutic modulation of NF-κB activity can suppress central oncogenic signaling pathways in GBM, but clinically applicable compounds to achieve this goal have remained elusive. METHODS: In a pharmacogenomics study with a panel of transgenic glioma cells, we observed that NF-κB can be converted into a tumor suppressor by the non-psychotropic canna...     »
Journal title abbreviation:
Neuro-oncol
Year:
2021
Journal volume:
23
Journal issue:
11
Pages contribution:
1898-1910
Fulltext / DOI:
doi:10.1093/neuonc/noab095
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33864076
Print-ISSN:
1522-8517
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Klinik und Poliklinik für Nuklearmedizin; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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