[Reporting and handling of lymphonodectomy specimens in gynecologic malignancies and sentinel lymph nodes].

Höhn, Anne Kathrin; Brambs, Christine E; Erber, Ramona; Hiller, Grit Gesine Ruth; Mayr, Doris; Schmidt, Dietmar; Schmoeckel, Elisa; Horn, Lars-Christian

doi:10.1007/s00292-020-00805-9

2021

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Title:: [Reporting and handling of lymphonodectomy specimens in gynecologic malignancies and sentinel lymph nodes].
Document type:: English Abstract; Journal Article; Review
Author(s):: Höhn, Anne Kathrin; Brambs, Christine E; Erber, Ramona; Hiller, Grit Gesine Ruth; Mayr, Doris; Schmidt, Dietmar; Schmoeckel, Elisa; Horn, Lars-Christian
Abstract:: The handling and reporting of resected lymph nodes in gynecologic cancer follows the recommendations of the German national guidelines and the recommendations of the International Collaboration of Cancer Reporting (ICCR) and the International Society of Gynecologic Pathologists (ISGyP). The definitions of micrometastases and isolated tumor cells are in accordance with the definition of the UICC (Union Internationale Contre le Cancer) and TNM system. Both findings must be reported as part of the pathology report and final tumor classification. It is mandatory to examine all excised lymph nodes with complete processing of all nodes up to 0.3 cm and slicing of all larger nodes in 0.2-cm wide intervals with complete processing of all lamellae. The amount of the resected lymph nodes in correlation to positive nodes, the metric dimension of the largest lymph node metastasis per lymph node region, and the presence of extracapsular extension of the lymph node deposits must be part of the pathology report. The handling and cutting of sentinel lymph nodes are similar to nonsentinel nodes. Within frozen section analyses and final processing from paraffin-embedded sentinel nodes, all nodes should be examined by three-step sections with an interval of about 200 µm. In cases of negative sentinel nodes on H&E staining, immunohistochemical ultrastaging should be performed.
Journal title abbreviation:: Pathologe
Year:: 2021
Journal volume:: 42
Journal issue:: 3
Pages contribution:: 319-327
Fulltext / DOI:: doi:10.1007/s00292-020-00805-9
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/32700061
Print-ISSN:: 0172-8113
TUM Institution:: Frauenklinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Frauenheilkunde (Prof. Kiechle)2021