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- Dokumenttyp:
- Journal Article
- Autor(en):
- Koppara, Tobias; Dregely, Isabel; Nekolla, Stephan G; Nährig, Jörg; Langwieser, Nicolas; Bradaric, Christian; Ganter, Carl; Laugwitz, Karl-Ludwig; Schwaiger, Markus; Ibrahim, Tareq
- Titel:
- Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease.
- Abstract:
- BACKGROUND: Simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a novel hybrid imaging method integrating the advances of morphological tissue characterization of MRI with the pathophysiological insights of PET applications. AIM: This study evaluated the use of simultaneous 18-FDG PET/MR imaging for characterizing atherosclerotic lesions in lower extremity arterial disease (LEAD). METHODS: Eight patients with symptomatic stenoses of the superficial femoral artery (SFA) under simultaneous acquisition of 18-FDG PET and contrast-enhanced MRI using an integrated whole-body PET/MRI scanner. Invasive plaque characterization of the SFA was performed by intravascular imaging using optical coherence tomography. Histological analysis of plaque specimens was performed after directional atherectomy. RESULTS: MRI showed contrast enhancement at the site of arterial stenosis, as assessed on T2-w and T1-w images, compared to a control area of the contralateral SFA (0.38 ± 0.15 cm vs. 0.23 ± 0.11 cm; 1.77 ± 0.19 vs. 1.57 ± 0.15; p-value <0.05). On PET imaging, uptake of 18F-FDG (target-to-background ratio TBR > 1) at the level of symptomatic stenosis was observed in all but one patient. Contrast medium-induced MR signal enhancement was detected in all plaques, whereas FDG uptake in PET imaging was increased in lesions with active fibroatheroma and reduced in fibrocalcified lesions. CONCLUSION: In this multimodal imaging study, we report the feasibility and challenges of simultaneous PET/MR imaging of LEAD, which might offer new perspectives for risk estimation.
- Zeitschriftentitel:
- Front Cardiovasc Med
- Jahr:
- 2024
- Band / Volume:
- 11
- Volltext / DOI:
- doi:10.3389/fcvm.2024.1352696
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/38404725
- TUM Einrichtung:
- Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)
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