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- Title:
Spectral computed tomography angiography using a gadolinium-based contrast agent for imaging of pathologies of the aorta.
- Document type:
- Journal Article; Evaluation Study
- Author(s):
- Graf, Markus; Gassert, Felix G; Marka, Alexander W; Gassert, Florian T; Ziegelmayer, Sebastian; Makowski, Marcus; Kallmayer, Michael; Nadjiri, Jonathan
- Abstract:
- OBJECTIVES: Especially patients with aortic aneurysms and multiple computed tomography angiographies (CTA) might show medical conditions which oppose the use of iodine-based contrast agents. CTA using monoenergetic reconstructions from dual layer CT and gadolinium (Gd-)based contrast agents might be a feasible alternative in these patients. Therefore, the purpose of this study was to evaluate the feasibility of clinical spectral CTA with a Gd-based contrast agent in patients with aortic aneurysms. METHODS: Twenty-one consecutive scans in 15 patients with and without endovascular aneurysm repair showing contraindications for iodine-based contrast agents were examined using clinical routine doses (0.2 mmol/kg) of Gd-based contrast agent with spectral CT. Monoenergetic reconstructions of the spectral data set were computed. RESULTS: There was a significant increase in the intravascular attenuation of the aorta between pre- and post-contrast images for the MonoE40 images in the thoracic and the abdominal aorta (p < 0.001 for both). Additionally, the ratio between pre- and post-contrast images was significantly higher in the MonoE40 images as compared to the conventional images with a factor of 6.5 ± 4.5 vs. 2.4 ± 0.5 in the thoracic aorta (p = 0.003) and 4.1 ± 1.8 vs. 1.9 ± 0.5 in the abdominal aorta (p < 0.001). CONCLUSIONS: To conclude, our study showed that Gd-CTA is a valid and reliable alternative for diagnostic imaging of the aorta for clinical applications. Monoenergetic reconstructions of computed tomography angiographies using gadolinium based contrast agents may be a useful alternative in patients with aortic aneurysms and contraindications for iodine based contrast agents.
- Journal title abbreviation:
- Int J Cardiovasc Imaging
- Year:
- 2024
- Journal volume:
- 40
- Journal issue:
- 5
- Pages contribution:
- 1059-1066
- Fulltext / DOI:
- doi:10.1007/s10554-024-03074-2
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/38421538
- Print-ISSN:
- 1569-5794
- TUM Institution:
- Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)
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