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Titel:

Proteomic Characterization of Undifferentiated Small Round Cell Sarcomas With EWSR1 and CIC::DUX4 Translocations Reveals Diverging Tumor Biology and Distinct Diagnostic Markers.

Dokumenttyp:
Journal Article
Autor(en):
Doll, Sophia; Schweizer, Lisa; Bollwein, Christine; Steiger, Katja; Pfarr, Nicole; Walker, Maria; Wörtler, Klaus; Knebel, Carolin; von Eisenhart-Rothe, Ruediger; Hartmann, Wolfgang; Weichert, Wilko; Mann, Matthias; Kuhn, Peer-Hendrik; Specht, Katja
Abstract:
Undifferentiated small round cell sarcomas (USRS) of bone and soft tissue are a group of tumors with heterogenic genomic alterations sharing similar morphology. In the present study, we performed a comparative large-scale proteomic analysis of USRS (n = 42) with diverse genomic translocations including classic Ewing sarcomas with EWSR1::FLI1 fusions (n = 24) or EWSR1::ERG fusions (n = 4), sarcomas with an EWSR1 rearrangement (n = 2), CIC::DUX4 fusion (n = 8), as well as tumors classified as USRS...     »
Zeitschriftentitel:
Mod Pathol
Jahr:
2024
Band / Volume:
37
Heft / Issue:
7
Volltext / DOI:
doi:10.1016/j.modpat.2024.100511
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38705279
Print-ISSN:
0893-3952
TUM Einrichtung:
Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)
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