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Title:

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

Document type:
Journal Article
Author(s):
Aden, Konrad; Tran, Florian; Ito, Go; Sheibani-Tezerji, Raheleh; Lipinski, Simone; Kuiper, Jan W; Tschurtschenthaler, Markus; Saveljeva, Svetlana; Bhattacharyya, Joya; Häsler, Robert; Bartsch, Kareen; Luzius, Anne; Jentzsch, Marlene; Falk-Paulsen, Maren; Stengel, Stephanie T; Welz, Lina; Schwarzer, Robin; Rabe, Björn; Barchet, Winfried; Krautwald, Stefan; Hartmann, Gunther; Pasparakis, Manolis; Blumberg, Richard S; Schreiber, Stefan; Kaser, Arthur; Rosenstiel, Philip
Abstract:
A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-22 is a barrier protective cytokine by inducing regeneration and antimicrobial responses in the intestinal mucosa. We show that ATG16L1 critically orchestrates IL-22 signaling in the intestinal epithelium. IL-22 stimulation physiologically leads to transient ER stress and subsequent activation of STING-dependent type I...     »
Journal title abbreviation:
J Exp Med
Year:
2018
Journal volume:
215
Journal issue:
11
Pages contribution:
2868-2886
Fulltext / DOI:
doi:10.1084/jem.20171029
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30254094
Print-ISSN:
0022-1007
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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