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Titel:

Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Rahn, Sascha; Zimmermann, Vivien; Viol, Fabrice; Knaack, Hendrike; Stemmer, Kerstin; Peters, Lena; Lenk, Lennart; Ungefroren, Hendrik; Saur, Dieter; Schäfer, Heiner; Helm, Ole; Sebens, Susanne
Abstract:
Type 2 diabetes mellitus (T2DM) is associated with hyperglycemia and a risk to develop pancreatic ductal adenocarcinoma (PDAC), one of the most fatal malignancies. Cancer stem cells (CSC) are essential for initiation and maintenance of tumors, and acquisition of CSC-features is linked to epithelial-mesenchymal-transition (EMT). The present study investigated whether hyperglycemia promotes EMT and CSC-features in premalignant and malignant pancreatic ductal epithelial cells (PDEC). Under normogly...     »
Zeitschriftentitel:
Cancer Lett
Jahr:
2018
Band / Volume:
415
Seitenangaben Beitrag:
129-150
Volltext / DOI:
doi:10.1016/j.canlet.2017.12.004
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29222037
Print-ISSN:
0304-3835
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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