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Title:

Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Besnard, Antoine; Gao, Yuan; TaeWoo Kim, Michael; Twarkowski, Hannah; Reed, Alexander Keith; Langberg, Tomer; Feng, Wendy; Xu, Xiangmin; Saur, Dieter; Zweifel, Larry S; Davison, Ian; Sahay, Amar
Abstract:
Adaptive fear responses to external threats rely upon efficient relay of computations underlying contextual encoding to subcortical circuits. Brain-wide analysis of highly coactivated ensembles following contextual fear discrimination identified the dorsolateral septum (DLS) as a relay of the dentate gyrus-CA3 circuit. Retrograde monosynaptic tracing and electrophysiological whole-cell recordings demonstrated that DLS somatostatin-expressing interneurons (SST-INs) receive direct CA3 inputs. Long...     »
Journal title abbreviation:
Nat Neurosci
Year:
2019
Journal volume:
22
Journal issue:
3
Pages contribution:
436-446
Fulltext / DOI:
doi:10.1038/s41593-018-0330-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30718902
Print-ISSN:
1097-6256
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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