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Title:

Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma.

Document type:
Journal Article
Author(s):
Jesinghaus, Moritz; Boxberg, Melanie; Wilhelm, Dirk; Münch, Stefan; Dapper, Hendrik; Quante, Michael; Schlag, Christoph; Lange, Sebastian; Budczies, Jan; Konukiewitz, Björn; Mollenhauer, Martin; Schlitter, Anna Melissa; Becker, Karl Friedrich; Feith, Marcus; Friess, Helmut; Steiger, Katja; Combs, Stephanie E; Weichert, Wilko
Abstract:
BACKGROUND: Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy. METHODS: We evaluated cell nest size and tumour budding activity in 122 post-neoadjuvant ESCC resections, correlated the results with tumour regression groups and patien...     »
Journal title abbreviation:
Br J Cancer
Year:
2019
Journal volume:
121
Journal issue:
12
Pages contribution:
1050-1057
Fulltext / DOI:
doi:10.1038/s41416-019-0623-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31690830
Print-ISSN:
0007-0920
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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