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Title:

Deciphering the universe of genetic context-dependencies using mouse models of cancer.

Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Falcomatà, Chiara; Bärthel, Stefanie; Schneider, Günter; Saur, Dieter; Veltkamp, Christian
Abstract:
Molecular profiling of cancer patients and modelling of human cancer in mice revealed cell type and tissue-specific differences in tumor development and evolution. However, the context-dependent determinants of cancer remain poorly understood. A systematic characterization of the biological underpinnings of context-specificity will, therefore, be pivotal to design more effective therapies. In this review article, we focus on recent advances on molecular, cellular and microenvironmental aspects o...     »
Journal title abbreviation:
Curr Opin Genet Dev
Year:
2019
Journal volume:
54
Pages contribution:
97-104
Fulltext / DOI:
doi:10.1016/j.gde.2019.04.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31078084
Print-ISSN:
0959-437X
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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