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Title:

A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Murakami, Shigekazu; Nemazanyy, Ivan; White, Shannon M; Chen, Hengye; Nguyen, Chan D K; Graham, Garrett T; Saur, Dieter; Pende, Mario; Yi, Chunling
Abstract:
Employing inducible genetically engineered and orthotopic mouse models, we demonstrate a key role for transcriptional regulator Yap in maintenance of Kras-mutant pancreatic tumors. Integrated transcriptional and metabolomics analysis reveals that Yap transcribes Myc and cooperates with Myc to maintain global transcription of metabolic genes. Yap loss triggers acute metabolic stress, which causes tumor regression while inducing epigenetic reprogramming and Sox2 upregulation in a subset of pancrea...     »
Journal title abbreviation:
Dev Cell
Year:
2019
Journal volume:
51
Journal issue:
1
Pages contribution:
113-128.e9
Fulltext / DOI:
doi:10.1016/j.devcel.2019.07.022
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31447265
Print-ISSN:
1534-5807
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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