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Titel:

Prognostic implication of molecular subtypes and response to neoadjuvant chemotherapy in 760 gastric carcinomas: role of Epstein-Barr virus infection and high- and low-microsatellite instability.

Dokumenttyp:
Journal Article
Autor(en):
Kohlruss, Meike; Grosser, Bianca; Krenauer, Marie; Slotta-Huspenina, Julia; Jesinghaus, Moritz; Blank, Susanne; Novotny, Alexander; Reiche, Magdalena; Schmidt, Thomas; Ismani, Liridona; Hapfelmeier, Alexander; Mathias, Daniel; Meyer, Petra; Gaida, Matthias M; Bauer, Lukas; Ott, Katja; Weichert, Wilko; Keller, Gisela
Abstract:
Epstein-Barr virus positivity (EBV(+)) and high-microsatellite instability (MSI-H) have been identified as molecular subgroups in gastric carcinoma. The aim of our study was to determine the prognostic and predictive relevance of these subgroups in the context of platinum/5-fluorouracil (5-FU) based preoperative chemotherapy (CTx). Additionally, we investigated the clinical relevance of the low-MSI (MSI-L) phenotype. We analysed 760 adenocarcinomas of the stomach or the gastro-oesophageal juncti...     »
Zeitschriftentitel:
J Pathol Clin Res
Jahr:
2019
Band / Volume:
5
Heft / Issue:
4
Seitenangaben Beitrag:
227-239
Volltext / DOI:
doi:10.1002/cjp2.137
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31206244
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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