Benutzer: Gast  Login
Titel:

A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Murakami, Shigekazu; Nemazanyy, Ivan; White, Shannon M; Chen, Hengye; Nguyen, Chan D K; Graham, Garrett T; Saur, Dieter; Pende, Mario; Yi, Chunling
Abstract:
Employing inducible genetically engineered and orthotopic mouse models, we demonstrate a key role for transcriptional regulator Yap in maintenance of Kras-mutant pancreatic tumors. Integrated transcriptional and metabolomics analysis reveals that Yap transcribes Myc and cooperates with Myc to maintain global transcription of metabolic genes. Yap loss triggers acute metabolic stress, which causes tumor regression while inducing epigenetic reprogramming and Sox2 upregulation in a subset of pancrea...     »
Zeitschriftentitel:
Dev Cell
Jahr:
2019
Band / Volume:
51
Heft / Issue:
1
Seitenangaben Beitrag:
113-128.e9
Volltext / DOI:
doi:10.1016/j.devcel.2019.07.022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31447265
Print-ISSN:
1534-5807
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
 BibTeX