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Titel:

Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.

Dokumenttyp:
Review; Journal Article; Review; Research Support, Non-U.S. Gov't
Autor(en):
Kabacaoglu, Derya; Ciecielski, Katrin J; Ruess, Dietrich A; Algül, Hana
Abstract:
Pancreatic ductal adenocarcinoma (PDAC), as the most frequent form of pancreatic malignancy, still is associated with a dismal prognosis. Due to its late detection, most patients are ineligible for surgery, and chemotherapeutic options are limited. Tumor heterogeneity and a characteristic structure with crosstalk between the cancer/malignant cells and an abundant tumor microenvironment (TME) make PDAC a very challenging puzzle to solve. Thus far, targeted therapies have failed to substantially i...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2018
Band / Volume:
9
Volltext / DOI:
doi:10.3389/fimmu.2018.01878
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30158932
Print-ISSN:
1664-3224
TUM Einrichtung:
Lehrstuhl für Tumormetabolismus (Prof. Algül)
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