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Titel:

The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.

Dokumenttyp:
Journal Article
Autor(en):
Hedegger, Kathrin; Stumpf, Franziska; Blum, Helmut; Graf, Alexander; Schmid, Roland Michael; Lesina, Marina; Algül, Hana; Schneider, Marlon Roberto; Dahlhoff, Maik
Abstract:
BACKGROUND: The EGFR ligand betacellulin (BTC) has been previously shown to protect mice against experimentally induced acute pancreatitis (AP). BTC binds both autonomous ERBB receptors EGFR and ERBB4. In this study, we evaluated the mechanism underlying the protection from AP-associated inflammation in detail. METHODS: AP was induced with cerulein or L-arginine and investigated in a pancreas-specific ERBB4 knockout and in an EGFR knockdown mouse model (EgfrWa5/+). Pancreatitis was evaluated by...     »
Zeitschriftentitel:
J Gastroenterol
Jahr:
2020
Band / Volume:
55
Heft / Issue:
3
Seitenangaben Beitrag:
317-329
Volltext / DOI:
doi:10.1007/s00535-019-01613-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31456099
Print-ISSN:
0944-1174
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Tumormetabolismus (Prof. Algül)
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