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Title:

The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.

Document type:
Journal Article
Author(s):
Hedegger, Kathrin; Stumpf, Franziska; Blum, Helmut; Graf, Alexander; Schmid, Roland Michael; Lesina, Marina; Algül, Hana; Schneider, Marlon Roberto; Dahlhoff, Maik
Abstract:
BACKGROUND: The EGFR ligand betacellulin (BTC) has been previously shown to protect mice against experimentally induced acute pancreatitis (AP). BTC binds both autonomous ERBB receptors EGFR and ERBB4. In this study, we evaluated the mechanism underlying the protection from AP-associated inflammation in detail. METHODS: AP was induced with cerulein or L-arginine and investigated in a pancreas-specific ERBB4 knockout and in an EGFR knockdown mouse model (EgfrWa5/+). Pancreatitis was evaluated by...     »
Journal title abbreviation:
J Gastroenterol
Year:
2020
Journal volume:
55
Journal issue:
3
Pages contribution:
317-329
Fulltext / DOI:
doi:10.1007/s00535-019-01613-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31456099
Print-ISSN:
0944-1174
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Lehrstuhl für Tumormetabolismus (Prof. Algül)
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