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- Title:
Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis.
- Document type:
- Journal Article; 56
- Author(s):
- Stachowiak, Monika; Flisikowska, Tatiana; Bauersachs, Stefan; Perleberg, Carolin; Pausch, Hubert; Switonski, Marek; Kind, Alexander; Saur, Dieter; Schnieke, Angelika; Flisikowski, Krzysztof
- Abstract:
- MicroRNAs are dysregulated in various cancers including colorectal cancer, and are potential useful biomarkers of disease development. We used next generation sequencing to investigate miRNA expression profiles in low- and high-grade intraepithelial dysplastic polyps from pigs carrying a mutation in the adenomatous polyposis coli tumour suppressor ( , orthologous to human ) that model an inherited predisposition to colorectal cancer, familial adenomatous polyposis. We identified several miRNAs and their isomiRs significantly ( < 0.05) differentially expressed between low and high-grade intraepithelial dysplastic polyps. Of these, ssc-let-7e, ssc-miR-98, ssc-miR-146a-5p, ssc-miR-146b, ssc-miR-183 and ssc-miR-196a were expressed at higher level and ssc-miR-126-3p at lower level in high-grade intraepithelial dysplastic polyps. Functional miRNA target analysis revealed significant ( < 0.001) over-representation of cancer-related pathways, including 'microRNAs in cancer', 'proteoglycans in cancer', 'pathways in cancer' and 'colorectal cancer'. This is the first study to reveal miRNAs associated with premalignant transformation of colon polyps.
- Journal title abbreviation:
- Oncotarget
- Year:
- 2017
- Journal volume:
- 8
- Journal issue:
- 56
- Pages contribution:
- 96154-96160
- Fulltext / DOI:
- doi:10.18632/oncotarget.21774
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/29221194
- TUM Institution:
- Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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