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Title:

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

Document type:
Journal Article
Author(s):
Zhang, Haikuo; Fillmore Brainson, Christine; Koyama, Shohei; Redig, Amanda J; Chen, Ting; Li, Shuai; Gupta, Manav; Garcia-de-Alba, Carolina; Paschini, Margherita; Herter-Sprie, Grit S; Lu, Gang; Zhang, Xin; Marsh, Bryan P; Tuminello, Stephanie J; Xu, Chunxiao; Chen, Zhao; Wang, Xiaoen; Akbay, Esra A; Zheng, Mei; Palakurthi, Sangeetha; Sholl, Lynette M; Rustgi, Anil K; Kwiatkowski, David J; Diehl, J Alan; Bass, Adam J; Sharpless, Norman E; Dranoff, Glenn; Hammerman, Peter S; Ji, Hongbin; Bardeesy...     »
Abstract:
Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including Sox2, ?Np63 and Ngfr. SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC les...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Pages contribution:
14922
Fulltext / DOI:
doi:10.1038/ncomms14922
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28387316
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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