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Title:

ROR? Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait.

Document type:
Journal Article; 6
Author(s):
Koch, Stephanie C; Del Barrio, Marta Garcia; Dalet, Antoine; Gatto, Graziana; Günther, Thomas; Zhang, Jingming; Seidler, Barbara; Saur, Dieter; Schüle, Roland; Goulding, Martyn
Abstract:
Animals depend on sensory feedback from mechanosensory afferents for the dynamic control of movement. This sensory feedback needs to be selectively modulated in a task- and context-dependent manner. Here, we show that inhibitory interneurons (INs) expressing the ROR? orphan nuclear receptor gate sensory feedback to the spinal motor system during walking and are required for the production of a fluid locomotor rhythm. Genetic manipulations that abrogate inhibitory ROR? IN function result in an at...     »
Journal title abbreviation:
Neuron
Year:
2017
Journal volume:
96
Journal issue:
6
Pages contribution:
1419-1431.e5
Fulltext / DOI:
doi:10.1016/j.neuron.2017.11.011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29224725
Print-ISSN:
0896-6273
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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