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Titel:

ROR? Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait.

Dokumenttyp:
Journal Article; 6
Autor(en):
Koch, Stephanie C; Del Barrio, Marta Garcia; Dalet, Antoine; Gatto, Graziana; Günther, Thomas; Zhang, Jingming; Seidler, Barbara; Saur, Dieter; Schüle, Roland; Goulding, Martyn
Abstract:
Animals depend on sensory feedback from mechanosensory afferents for the dynamic control of movement. This sensory feedback needs to be selectively modulated in a task- and context-dependent manner. Here, we show that inhibitory interneurons (INs) expressing the ROR? orphan nuclear receptor gate sensory feedback to the spinal motor system during walking and are required for the production of a fluid locomotor rhythm. Genetic manipulations that abrogate inhibitory ROR? IN function result in an at...     »
Zeitschriftentitel:
Neuron
Jahr:
2017
Band / Volume:
96
Heft / Issue:
6
Seitenangaben Beitrag:
1419-1431.e5
Volltext / DOI:
doi:10.1016/j.neuron.2017.11.011
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29224725
Print-ISSN:
0896-6273
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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