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Title:

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review; 5
Author(s):
Gukovskaya, Anna S; Gukovsky, Ilya; Algül, Hana; Habtezion, Aida
Abstract:
Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease severity depends on whether the inflammatory response resolves or amplifies, leading to multi-organ failure. Dysregulated autophagy might promote the inflammatory response in the p...     »
Journal title abbreviation:
Gastroenterology
Year:
2017
Journal volume:
153
Journal issue:
5
Pages contribution:
1212-1226
Fulltext / DOI:
doi:10.1053/j.gastro.2017.08.071
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28918190
Print-ISSN:
0016-5085
TUM Institution:
Lehrstuhl für Tumormetabolismus (Prof. Algül)
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