New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.

Title:: New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.
Document type:: Journal Article; Comment
Author(s):: Diakopoulos, Kalliope N; Algül, Hana
Abstract:: Obesity and acute pancreatitis are both proinflammatory conditions. Importantly, obesity increases severity in acute pancreatitis by enhancing inflammation. In a recent issue of The Journal of Pathology, Pérez and Ruiz-Pérez et al connected obesity and pancreatitis for the first time, through the transcriptional regulator PPARγ coactivator 1α (PGC-1α). Obesity reduces pancreatic PGC-1α levels and potentiates not only oxidative but also IL-6-mediated inflammatory damage during acute pancreatitis by relieving the binding of PGC-1α to the NF-κB subunit p65. Blockade of the IL-6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC-1α/p65/IL-6 signaling in obesity and acute pancreatitis. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Journal title abbreviation:: J Pathol
Year:: 2019
Journal volume:: 248
Journal issue:: 1
Pages contribution:: 6-8
Fulltext / DOI:: doi:10.1002/path.5220
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/30570131
Print-ISSN:: 0022-3417
TUM Institution:: Lehrstuhl für Tumormetabolismus (Prof. Algül)
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