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Title:

CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma.

Document type:
Journal Article
Author(s):
Fang, Hsin-Yu; Münch, Natasha Stephens; Schottelius, Margret; Ingermann, Jonas; Liu, Haibo; Schauer, Michael; Stangl, Stefan; Multhoff, Gabriele; Steiger, Katja; Gerngroß, Carlos; Jesinghaus, Moritz; Weichert, Wilko; Kühl, Anja A; Sepulveda, Antonia R; Wester, Hans-Jürgen; Wang, Timothy C; Quante, Michael
Abstract:
Purpose: Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of Barrett's esophagus and esophageal adenocarcinoma.Experimental Design: Here we utilized an IL1β transgenic mouse model of Barrett's esophagus and esophageal adenocarcinoma and human patient imaging to analyze the importance of CXCR4-expressing cells during esophageal...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2018
Journal volume:
24
Journal issue:
5
Pages contribution:
1048-1061
Language:
eng
Fulltext / DOI:
doi:10.1158/1078-0432.CCR-17-1756
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29208671
Print-ISSN:
1078-0432
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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