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Title:

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Chen, Yang; LeBleu, Valerie S; Carstens, Julienne L; Sugimoto, Hikaru; Zheng, Xiaofeng; Malasi, Shruti; Saur, Dieter; Kalluri, Raghu
Abstract:
Epithelial-to-mesenchymal transition (EMT) is a recognized eukaryotic cell differentiation program that is also observed in association with invasive tumors. Partial EMT program in carcinomas imparts cancer cells with mesenchymal-like features and is proposed as essential for metastasis. Precise determination of the frequency of partial EMT program in cancer cells in tumors and its functional role in metastases needs unraveling. Here, we employed mesenchymal cell reporter mice driven by αSMA-Cre...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2018
Journal volume:
10
Journal issue:
10
Fulltext / DOI:
doi:10.15252/emmm.201809085
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30120146
Print-ISSN:
1757-4676
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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