User: Guest  Login
More Searchfields
Simple search
Title:

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.

Document type:
Journal Article
Author(s):
Cheung, Phyllis F; Neff, Florian; Neander, Christian; Bazarna, Anna; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Althoff, Kristina; Lee, Chang-Lung; Moding, Everett J; Kirsch, David G; Saur, Dieter; Bazhin, Alexandr V; Trajkovic-Arsic, Marija; Heikenwalder, Mathias F; Siveke, Jens T
Abstract:
Despite advances in our understanding of the genetics of pancreatic ductal adenocarcinoma (PDAC), the efficacy of therapeutic regimens targeting aberrant signaling pathways remains highly limited. Therapeutic strategies are greatly hampered by the extensive desmoplasia that comprises heterogeneous cell populations. Notch signaling is a contentious pathway exerting opposite roles in tumorigenesis depending on cellular context. Advanced model systems are needed to gain more insights into complex s...     »
Journal title abbreviation:
Cancer Res
Year:
2018
Journal volume:
78
Journal issue:
17
Pages contribution:
4997-5010
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-18-0052
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29844119
Print-ISSN:
0008-5472
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
 BibTeX