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Title:

Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wang, Lele; Zhao, Linlin; Wei, Guo; Saur, Dieter; Seidler, Barbara; Wang, Junyan; Wang, Chuanxin; Qi, Tonggang
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating disease with the 5-year survival rate less than 6%. In this study, we investigated if inhibiting protein synthesis directly with homoharringtonine (HHT) could induce acute apoptosis in pancreatic cancer cells through quick depletion of multiple short-lived critical members of the central proteome, example, PSMD11(26S proteasome non-ATPase regulatory subunit 11). It was shown that although HHT could inhibit proliferation...     »
Journal title abbreviation:
J Cell Biochem
Year:
2018
Journal volume:
119
Journal issue:
8
Pages contribution:
6644-6656
Fulltext / DOI:
doi:10.1002/jcb.26847
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29665121
Print-ISSN:
0730-2312
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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