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Titel:

c-Kit+ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells.

Dokumenttyp:
Journal Article
Autor(en):
Kwak, Mingyu; Ninche, Ninche; Klein, Sabine; Saur, Dieter; Ghazizadeh, Soosan
Abstract:
A rare population of salivary gland cells isolated based on c-Kit immunoreactivity are thought to represent tissue stem cells since they exhibit the most robust proliferative and differentiation capacity ex vivo. Despite their high promise for cell-based therapies aimed at restoring salivary function, the precise location and in vivo function of c-Kit+ stem cells remain unclear. Here, by combining immunostaining with c-KitCreERT2-based genetic labeling and lineage tracing in the adult mouse sali...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2018
Band / Volume:
8
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-018-32557-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30242278
Print-ISSN:
2045-2322
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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