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Titel:

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.

Dokumenttyp:
Journal Article
Autor(en):
Cheung, Phyllis F; Neff, Florian; Neander, Christian; Bazarna, Anna; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Althoff, Kristina; Lee, Chang-Lung; Moding, Everett J; Kirsch, David G; Saur, Dieter; Bazhin, Alexandr V; Trajkovic-Arsic, Marija; Heikenwalder, Mathias F; Siveke, Jens T
Abstract:
Despite advances in our understanding of the genetics of pancreatic ductal adenocarcinoma (PDAC), the efficacy of therapeutic regimens targeting aberrant signaling pathways remains highly limited. Therapeutic strategies are greatly hampered by the extensive desmoplasia that comprises heterogeneous cell populations. Notch signaling is a contentious pathway exerting opposite roles in tumorigenesis depending on cellular context. Advanced model systems are needed to gain more insights into complex s...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2018
Band / Volume:
78
Heft / Issue:
17
Seitenangaben Beitrag:
4997-5010
Volltext / DOI:
doi:10.1158/0008-5472.CAN-18-0052
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29844119
Print-ISSN:
0008-5472
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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