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Titel:

Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Alonso-Nocelo, Marta; Ruiz-Cañas, Laura; Sancho, Patricia; Görgülü, Kıvanç; Alcalá, Sonia; Pedrero, Coral; Vallespinos, Mireia; López-Gil, Juan Carlos; Ochando, Marina; García-García, Elena; David Trabulo, Sara Maria; Martinelli, Paola; Sánchez-Tomero, Patricia; Sánchez-Palomo, Carmen; Gonzalez-Santamaría, Patricia; Yuste, Lourdes; Wörmann, Sonja Maria; Kabacaoğlu, Derya; Earl, Julie; Martin, Alberto; Salvador, Fernando; Valle, Sandra; Martin-Hijano, Laura; Carrato, Alfredo; Erkan, Mert; García-...     »
Abstract:
OBJECTIVE: The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models. DESIGN: Towards this end, we used PDAC patient data sets, patient-derived xenograft in vivo and in vitro models, and four conditional genetically-engineered mouse models (GEMMS) to dissect the role of LOXL2 in PDAC. For GEMM-based studies, K-Ras +/LS...     »
Zeitschriftentitel:
Gut
Jahr:
2023
Band / Volume:
72
Heft / Issue:
2
Seitenangaben Beitrag:
345-359
Volltext / DOI:
doi:10.1136/gutjnl-2021-325564
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35428659
Print-ISSN:
0017-5749
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Lehrstuhl für Tumormetabolismus (Prof. Algül)
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