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Titel:

Distinct Pathogenesis of Pancreatic Cancer Microvesicle-Associated Venous Thrombosis Identifies New Antithrombotic Targets In Vivo.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Stark, Konstantin; Schubert, Irene; Joshi, Urjita; Kilani, Badr; Hoseinpour, Parandis; Thakur, Manovriti; Grünauer, Petra; Pfeiler, Susanne; Schmidergall, Tobias; Stockhausen, Sven; Bäumer, Markus; Chandraratne, Sue; von Brühl, Marie-Luise; Lorenz, Michael; Coletti, Raffaele; Reese, Sven; Laitinen, Iina; Wörmann, Sonja Maria; Algül, Hana; Bruns, Christiane J; Ware, Jerry; Mackman, Nigel; Engelmann, Bernd; Massberg, Steffen
Abstract:
Cancer patients are at high risk of developing deep venous thrombosis (DVT) and venous thromboembolism, a leading cause of mortality in this population. However, it is largely unclear how malignant tumors drive the prothrombotic cascade culminating in DVT.Here, we addressed the pathophysiology of malignant DVT compared with nonmalignant DVT and focused on the role of tumor microvesicles as potential targets to prevent cancer-associated DVT. We show that microvesicles released by pancreatic adeno...     »
Zeitschriftentitel:
Arterioscler Thromb Vasc Biol
Jahr:
2018
Band / Volume:
38
Heft / Issue:
4
Seitenangaben Beitrag:
772-786
Volltext / DOI:
doi:10.1161/ATVBAHA.117.310262
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29419408
Print-ISSN:
1079-5642
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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