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Title:

Role of immune responses in the development of NAFLD-associated liver cancer and prospects for therapeutic modulation.

Document type:
Review; Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Yahoo, Neda; Dudek, Michael; Knolle, Percy; Heikenwälder, Mathias
Abstract:
The liver is the central metabolic organ of the body, regulating energy and lipid metabolism, while also having potent immunological functions. Overwhelming the metabolic capacity of the liver via obesity and a sedentary lifestyle leads to hepatic lipid accumulation, chronic necro-inflammation, enhanced mitochondrial/endoplasmic reticulum stress and development of non-alcoholic fatty liver disease (NAFLD), and its more severe form non-alcoholic steatohepatitis (NASH). Based on an improved unders...     »
Journal title abbreviation:
J Hepatol
Year:
2023
Journal volume:
79
Journal issue:
2
Pages contribution:
538-551
Fulltext / DOI:
doi:10.1016/j.jhep.2023.02.033
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36893854
Print-ISSN:
0168-8278
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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