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Title:

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance

Document type:
Zeitschriftenaufsatz
Author(s):
Phan, Tamara; Maity, Pallab; Ludwig, Christina; Streit, Lisa; Michaelis, Jens; Tsesmelis, Miltiadis; Scharffetter-Kochanek, Karin; Iben, Sebastian
Abstract:
Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiation site of protein-coding genes. Distinct mutations in TFIIH and TFIIE give rise to the degenerative disorder trichothiodystrophy (TTD). Here, we uncovered an unexpected role of TFIIE in ribosomal RNA synthesis by RNA polymerase I. With high resolutio...     »
Keywords:
BayBioMS
Journal title:
Nucleic Acids Research
Year:
2021
Fulltext / DOI:
doi:10.1093/nar/gkab866
Publisher:
Oxford University Press (OUP)
E-ISSN:
0305-10481362-4962
Date of publication:
28.09.2021
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