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Titel:

High-Fructose Diet Alters Intestinal Microbial Profile and Correlates with Early Tumorigenesis in a Mouse Model of Barrett’s Esophagus

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Proaño-Vasco, Andrea; Baumeister, Theresa; Metwaly, Amira; Reitmeier, Sandra; Kleigrewe, Karin; Meng, Chen; Gigl, Michael; Engleitner, Thomas; Öllinger, Rupert; Rad, Roland; Steiger, Katja; Anand, Akanksha; Strangmann, Julia; Thimme, Robert; Schmid, Roland M.; Wang, Timothy C.; Quante, Michael
Abstract:
Esophageal adenocarcinoma (EAC) is mostly prevalent in industrialized countries and has been associated with obesity, commonly linked with a diet rich in fat and refined sugars containing high fructose concentrations. In meta-organisms, dietary components are digested and metabolized by the host and its gut microbiota. Fructose has been shown to induce proliferation and cell growth in pancreas and colon cancer cell lines and also alter the gut microbiota. In a previous study with the L2-IL-1B mo...     »
Stichworte:
BayBioMS; Barrett’s esophagus; IL-1B-mouse model; Western diet; esophageal adenocarcinoma; fructose; metabolism; microbiota
Zeitschriftentitel:
Microorganisms
Jahr:
2021
Band / Volume:
9
Heft / Issue:
12
Seitenangaben Beitrag:
2432
Volltext / DOI:
doi:10.3390/microorganisms9122432
Verlag / Institution:
MDPI AG
E-ISSN:
2076-2607
Publikationsdatum:
25.11.2021
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