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Titel:

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Phan, Tamara; Maity, Pallab; Ludwig, Christina; Streit, Lisa; Michaelis, Jens; Tsesmelis, Miltiadis; Scharffetter-Kochanek, Karin; Iben, Sebastian
Abstract:
Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiation site of protein-coding genes. Distinct mutations in TFIIH and TFIIE give rise to the degenerative disorder trichothiodystrophy (TTD). Here, we uncovered an unexpected role of TFIIE in ribosomal RNA synthesis by RNA polymerase I. With high resolutio...     »
Stichworte:
BayBioMS
Zeitschriftentitel:
Nucleic Acids Research
Jahr:
2021
Volltext / DOI:
doi:10.1093/nar/gkab866
Verlag / Institution:
Oxford University Press (OUP)
E-ISSN:
0305-10481362-4962
Publikationsdatum:
28.09.2021
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