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Title:

Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells.

Document type:
Article; Journal Article
Author(s):
Erber, Johanna; Steiner, Joachim D; Isensee, Jörg; Lobbes, Leonard A; Toschka, André; Beleggia, Filippo; Schmitt, Anna; Kaiser, Rainer W J; Siedek, Florian; Persigehl, Thorsten; Hucho, Tim; Reinhardt, Hans C
Abstract:
The advent of molecularly targeted therapeutic agents has opened a new era in cancer therapy. However, many tumors rely on nondruggable cancer-driving lesions. In addition, long-lasting clinical benefits from single-agent therapies rarely occur, as most of the tumors acquire resistance over time. The identification of targeted combination regimens interfering with signaling through oncogenically rewired pathways provides a promising approach to enhance efficacy of single-agent-targeted treatment...     »
Journal title abbreviation:
Cancer Res
Year:
2019
Journal volume:
79
Journal issue:
19
Pages contribution:
4855-4868
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-18-3959
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31405847
Print-ISSN:
0008-5472
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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