Risk factors for bleeding from gastrointestinal angiodysplasia: a   case-control study in patients with bleeding and non-bleeding   angiodysplasia

Neu, Bruno; Moessmer, Georg; Bajbouj, Monther; Becker, Valentin; Barthel, Petra; Seidl, Holger; Schepp, Wolfgang; Anzinger, Michael; Dollhopf, Markus; Meining, Alexander; Schmid, Roland M.; Budde, Ulrich; Noe, Sebastian

doi:10.1055/a-1068-3014

journal article

Title:: Risk factors for bleeding from gastrointestinal angiodysplasia: a case-control study in patients with bleeding and non-bleeding angiodysplasia
Document type:: Article
Author(s):: Neu, Bruno; Moessmer, Georg; Bajbouj, Monther; Becker, Valentin; Barthel, Petra; Seidl, Holger; Schepp, Wolfgang; Anzinger, Michael; Dollhopf, Markus; Meining, Alexander; Schmid, Roland M.; Budde, Ulrich; Noe, Sebastian
Abstract:: Objectives Angiodysplasia (AD) is a common source of gastrointestinal bleeding. Yet, little is known about factors forwarding bleeding in these vascular malformations. The presented study aims to determine risk factors for bleeding that occurs only in patients with symptomatic, but not with asymptomatic, AD. Methods Case-control study in patients with AD and either a positive or a negative history of gastrointestinal bleeding in Munich, Germany. Groups were compared by clinical, laboratory, and endoscopic features. Results 80 patients with (58, f 31, med. age 72) or without bleeding AD(22, f 12, med. age 61) were included. Bleeding from ADwas significantly associated with the total number of AD (OR 1.4 (95 % CI 1.1-1.7) p = 0.01) and closure time in PFA/collagen-epinephrine test (OR 1.0 (95 % CI 1.0-1.0) p < 0.01). The total number of AD correlated significantly with age (r = 0.36; p = 0.01). AD were mainly detected in the upper small intestine (> 30 %). Although patients with aortic stenosis suffered not significantly more frequently from bleeding from AD, they demonstrated a loss of high molecular multimers of VWF. Conclusions The amount of AD is clearly correlated to the age of the patient. A higher number of ADs and inhibition of primary hemostasis increase the risk of bleeding.
Journal title abbreviation:: Z Gastroenterol
Year:: 2020
Journal volume:: 58
Journal issue:: 3
Pages contribution:: 234-240
Fulltext / DOI:: doi:10.1055/a-1068-3014
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/32018316
Print-ISSN:: 0044-2771
TUM Institution:: I. Medizinische Klinik und Poliklinik (Kardiologie); II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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