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Titel:

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.

Dokumenttyp:
Journal Article
Autor(en):
Franzmeier, Nicolai; Ren, Jinyi; Damm, Alexander; Monté-Rubio, Gemma; Boada, Mercè; Ruiz, Agustín; Ramirez, Alfredo; Jessen, Frank; Düzel, Emrah; Rodríguez Gómez, Octavio; Benzinger, Tammie; Goate, Alison; Karch, Celeste M; Fagan, Anne M; McDade, Eric; Buerger, Katharina; Levin, Johannes; Duering, Marco; Dichgans, Martin; Suárez-Calvet, Marc; Haass, Christian; Gordon, Brian A; Lim, Yen Ying; Masters, Colin L; Janowitz, Daniel; Catak, Cihan; Wolfsgruber, Steffen; Wagner, Michael; Milz, Esther; Mo...     »
Abstract:
In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline, rendering BDNFVal66Met an important modulating factor of cognitive impairment in AD. However, the effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we...     »
Zeitschriftentitel:
Mol Psychiatry
Jahr:
2021
Band / Volume:
26
Heft / Issue:
2
Seitenangaben Beitrag:
614-628
Volltext / DOI:
doi:10.1038/s41380-019-0404-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30899092
Print-ISSN:
1359-4184
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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