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Titel:

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia.

Dokumenttyp:
Article; Journal Article
Autor(en):
Mangolini, Maurizio; Götte, Frederik; Moore, Andrew; Ammon, Tim; Oelsner, Madlen; Lutzny-Geier, Gloria; Klein-Hitpass, Ludger; Williamson, James C; Lehner, Paul J; Dürig, Jan; Möllmann, Michael; Rásó-Barnett, Lívia; Hughes, Katherine; Santoro, Antonella; Méndez-Ferrer, Simón; Oostendorp, Robert A J; Zimber-Strobl, Ursula; Peschel, Christian; Hodson, Daniel J; Schmidt-Supprian, Marc; Ringshausen, Ingo
Abstract:
The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL), is activated in only a subset of patients through somatic mutations. Here we describe alternative, microenvironment-dependent mechanisms of Wnt activation in malignant B cells. We show that tumour cells specifically induce Notch2 activity in mesenchymal stromal cells (MSCs) required for the transcription of the complement factor C1q. MSC-derived C1q in turn inhibits Gsk3-β mediated degradati...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2018
Band / Volume:
9
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-018-06069-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30242258
Print-ISSN:
2041-1723
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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