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Titel:

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.

Dokumenttyp:
Journal Article
Autor(en):
Keuper, Michaela; Sachs, Stephan; Walheim, Ellen; Berti, Lucia; Raedle, Bernhard; Tews, Daniel; Fischer-Posovszky, Pamela; Wabitsch, Martin; Hrab? de Angelis, Martin; Kastenmüller, Gabi; Tschöp, Matthias H; Jastroch, Martin; Staiger, Harald; Hofmann, Susanna M
Abstract:
Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (M?s), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial function. As mitochondrial dysfunction has been associated with obesity and the metabolic syndrome in humans, herein we aimed to delineate how human macrophages may affect energy metabolism of white adipocytes.Human adipose tissue gene expression analysis for m...     »
Zeitschriftentitel:
Mol Metab
Jahr:
2017
Band / Volume:
6
Heft / Issue:
10
Seitenangaben Beitrag:
1226-1239
Volltext / DOI:
doi:10.1016/j.molmet.2017.07.008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29031722
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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