Tschöp, Matthias H; Stumvoll, Michael; Ristow, Michael
Titel:
Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.
Abstract:
Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.