Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.

Dokumenttyp:: Journal Article; Editorial Material
Autor(en):: Tschöp, Matthias H; Stumvoll, Michael; Ristow, Michael
Titel:: Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.
Abstract:: Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.
Zeitschriftentitel:: Cell Metab
Jahr:: 2016
Band / Volume:: 23
Heft / Issue:: 6
Seitenangaben Beitrag:: 959-60
Volltext / DOI:: doi:10.1016/j.cmet.2016.05.017
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/27304493
Print-ISSN:: 1550-4131
TUM Einrichtung:: Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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