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Titel:

First-in-human Phase I studies of PRS-080#22, a hepcidin antagonist, in healthy volunteers and patients with chronic kidney disease undergoing hemodialysis.

Dokumenttyp:
Article; Journal Article
Autor(en):
Renders, Lutz; Budde, Klemens; Rosenberger, Christian; van Swelm, Rachel; Swinkels, Dorine; Dellanna, Frank; Feuerer, Werner; Wen, Ming; Erley, Christiane; Bader, Birgit; Sommerer, Claudia; Schaier, Matthias; Meurer, Karoline; Matis, Louis
Abstract:
In chronic kidney disease both renal insufficiency and chronic inflammation trigger elevated hepcidin levels, which impairs iron uptake, availability. and erythropoiesis. Here we report the two first-in-human phase 1 trials of PRS-080#22, a novel, rationally engineered Anticalin protein that targets and antagonizes hepcidin. A single intravenous infusion of placebo or PRS-080#22 was administered to 48 healthy volunteers (phase 1a) and 24 patients with end stage chronic kidney disease (CKD) on he...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2019
Band / Volume:
14
Heft / Issue:
3
Volltext / DOI:
doi:10.1371/journal.pone.0212023
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30917125
Print-ISSN:
1932-6203
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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