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Title:

Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies-the German Cancer Consortium approach

Document type:
Review
Author(s):
Krackhardt, Angela M.; Anliker, Brigitte; Hildebrandt, Martin; Bachmann, Michael; Eichmueller, Stefan B.; Nettelbeck, Dirk M.; Renner, Matthias; Uharek, Lutz; Willimsky, Gerald; Schmitt, Michael; Wels, Winfried S.; Schuessler-Lenz, Martina
Abstract:
Adoptive transfer of T cells genetically modified by TCRs or CARs represents a highly attractive novel therapeutic strategy to treat malignant diseases. Various approaches for the development of such gene therapy medicinal products (GTMPs) have been initiated by scientists in recent years. To date, however, the number of clinical trials commenced in Germany and Europe is still low. Several hurdles may contribute to the delay in clinical translation of these therapeutic innovations including the...     »
Journal title abbreviation:
Cancer Immunol Immunother
Year:
2018
Journal volume:
67
Journal issue:
4
Pages contribution:
513-523
Fulltext / DOI:
doi:10.1007/s00262-018-2119-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29380009
Print-ISSN:
0340-7004
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Kliniken und Institute
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